I have PaperPort Pro 14 installed on my Windows 7 (32 bit) desktop computer and an Epson WorkForce 610 multifunction device (printer, scanner, FAX, copier) out on my LAN. I installed the latest Epson driver & utilities package for that printer and OS on that desktop machine. When I log into the desktop as an Administrator, everything works great. When I log in as a standard user, everything except scanning from Nuance works. I tested the Epson Scan application from Epson, and I tested scanning from OpenOffice.org 3.4.1; those work. In PaperPort, when I select the "Scan Settings" tab under the Desktop menu, the "Scan" button stays grayed out. Even if I click on "Select..." and pick "TWAIN: EPSON WorkForce 610" (the only choice) and click "OK" (as opposed to "Cancel" or "Advanced setup"), and then OK to the confirmation window, the "Scan" button stays grayed out.
If I (as a standard user) pick "Advanced setup" instead of "OK" in the "Select..." dialog, the pop-up window goes away and nothing more visible happens.
If, while logged in as a standard user, I run PaperPort "as an administrator", then scanning setup and usage works fine.
Running the `sfc` command in a command window as an administrator finds nothing.